The primary focus of our work is on understanding the neural systems underlying complex psychological phenomena like learning, memory, and emotion. We are interested in how memory is stored in the brain, how experience and learning can modify the nervous system, and how brain systems work together to solve these problems. While the emphasis in my lab is on basic science rather than on neuropathology or mental disorders, some of the fundamental questions we're addressing can relate to clinical problems. We take a multi-level approach which includes molecular neurobiology, functional brain imaging, and behavioral studies in humans and laboratory animals.
I am currently interested in taking new Ph.D. students and postdocs. Federally funded RA positions are available to qualified students. Please feel free to contact me or visit our web site for further details.
Izumi, H. , Kawahata, I. , Shinoda, Y. , Helmstetter, F. J., & Fukunaga, K. (2020)
SAK3 Administration Improves Spine Abnormalities and Cognitive Deficits in App(NL-G-F/NL-G-F) Knock-in Mice by Increasing Proteasome Activity through CaMKII/Rpt6 Signaling.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,
21(11).
Dulka, B. N., Pullins, S. E., Cullen, P. K., Moyer, J. R., & Helmstetter, F. J.(2020)
Age-related memory deficits are associated with changes in protein degradation in brain regions critical for trace fear conditioning.Neurobiology of aging,
91, 160-166.
Ferrara, N. C., Jarome, T. J., Cullen, P. K., Orsi, S. A., Kwapis, J. L., Trask, S. , Pullins, S. E., & Helmstetter, F. J.(2019)
GluR2 endocytosis-dependent protein degradation in the amygdala mediates memory updating.SCIENTIFIC REPORTS,
9.
De La Rosa, Israel J., . , Azimipour, M. , Cullen, P. K., Helmstetter, F. J., & Pashaie, R. (2018)
Angularly Resolved Deep Brain Fluorescence Imaging Using a Single Optical Fiber.INTERNATIONAL JOURNAL OF OPTICS,
2018.
Belleau, E. L., Pedersen, W. S., Miskovich, T. A., Helmstetter, F. J., & Larson, C. L.(2018)
Cortico-limbic connectivity changes following fear extinction and relationships with trait anxiety.SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE,
13(10), 1037-1046.
Azimipour, M. , Sheikhzadeh, M. , Baumgartner, R. , Cullen, P. K., Helmstetter, F. J., Chang, W. , & Pashaie, R. (2017)
Fluorescence laminar optical tomography for brain imaging: system implementation and performance evaluation.JOURNAL OF BIOMEDICAL OPTICS,
22(1).
Ferrara, N. C., Cullen, P. K., Pullins, S. P., Rotondo, E. K., & Helmstetter, F. J.(2017)
Input from the medial geniculate nucleus modulates amygdala encoding of fear memory discrimination.LEARNING & MEMORY,
24(9), 414-421.